Chris Sale gave up six hits and four earned runs in the first four innings, giving Baltimore all the cushion it needed. The Orioles added two runs off of Phil Humber who threw the final four innings for the White Sox, giving up five hits.
Baltimore tagged each White Sox pitcher for one home run, a solo shot by Lew Ford in the third inning and another by Adam Jones in the seventh.
For Baltimore, Chris Tillman gave up just one hit and no runs in seven innings of work. Brian Matusz took over in the eighth and picked up right where Tillman left off, closing out the game with two innings of one-hit baseball.
Adam Dunn and Dayan Viciedo had the two hits for Chicago. Adding to Chicago's offensive stuggles was an 0-for-4 mark with runners in scoring position and six runners stranded on base.
Nate McLouth was 3-for-4 on the night for Baltimore. Nick Markakis collected three RBI while going 1-for-4.
The White Sox are now 71-57 on the season and 1.5 games ahead of the Detroit Tigers in the AL Central race. The White Sox will look to win their first game of the series tomorrow at 6:05 p.m. CT and 7:05 p.m. ET.