Carlos Zambrano (11-6) finished his tumultuous 2010 campaign on an eight- decision winning streak, allowing three runs -- two earned -- on three hits and three walks in 6 1/3 innings for Chicago, which has won three straight, including the first two in this three-game series.
J.A. Happ (6-4) was tagged for eight runs -- seven earned -- on eight hits and five walks in just three-plus frames. The left-hander was winless in his final five starts of the season for Houston, which has dropped three in a row.
The Cubs loaded the bases in the second and fourth frames, with Byrd knocking in a pair with a single in the former and Ramirez blasting his ninth career grand slam in the latter, ending Happ's outing.
Zambrano had his 19-inning scoreless streak snapped in the seventh when Hunter Pence scored on Chris Johnson's fielder's choice. Brett Wallace followed with a two-run double to the left-field gap, but that was as close as Houston got.
Chicago has surrendered three or fewer runs in 15 straight road games... Zambrano lowered his earned-run average from 5.61 to 3.33 since returning to the rotation on August 9...Chicago's bullpen has a streak of 26 consecutive scoreless innings...Ryan Dempster will toe the rubber for the Cubs in the season finale on Sunday opposite Nelson Figueroa; Wandy Rodriguez, the originally scheduled starter, was scratched.