The Bulls scored 52 second-half points to break a halftime tie with the 76ers and earn the win.
Chicago improved to 8-7 with the win, while the 76ers fell to 10-7.
Luol Deng scored a game-high 25 points to help the the Bulls' offense. He also had seven rebounds and seven assists.
Richard Hamilton chipped in with 15 points. Joakim Noah and Carlos Boozer each racked up double-doubles. Noah had 12 points and 13 rebounds, while Boozer finished with 12 points and 12 rebounds.
Jrue Holiday finished with a team-high 23 points to lead the 76ers.
Chicago has a busy week ahead, with two games on the road and two at home. The Bulls are back in action Tuesday at home against the Indiana Pacers. Then they'll turn around and travel to play the Cleveland Cavaliers on Wednesday night.