Chicago starting pitcher Jose Quintana (5-4) took a 3-0 lead to the second inning but the left-hander was able to record just one out before the Twins knocked him out of the game. By the time the inning was finished, Quintana was on the hook for seven runs thanks to six singles and two walks.
Among Minnesota's 17 hits, only three were for extra bases, but all of those singles combined with eight walks by Chicago's pitchers helped generate the lopsided final score. Much of that happened in the fifth inning when the Twins sent 14 batters to the plate and scored 10 runs. Reliever Philip Humber gave up eight of those runs as the Twins blew open the game for good.
Scott Diamond (11-6) earned the win on the mound for the Twins, taking advantage of some generous run support while giving up four runs in five innings.
Chicago maintained their one-game lead in the AL Central division with second-place Detroit also losing to the Cleveland Indians. The White Sox and Twins complete their series Wednesday afternoon at 1:10 p.m. CT.