Buehrle, who is 2-0 with a 3.32 ERA in his past three starts, most recently earned the victory in a 12-2 decision over Detroit on Tuesday. In that game, the veteran left-hander went 7 2/3 innings, allowing two earned runs and seven hits.
In his career against Baltimore, Buehrle has gone 5-3 with a 2.91 earned run average over 12 starts.
The Orioles are set to counter with Jeremy Guthrie, who is seeking his third victory in four outings. The right-hander was last in action on Tuesday, when he gave up three earned runs and five hits over seven innings of a 6-3 triumph versus the Angels. He is now 2-1 with a 1.95 ERA in his last four starts.
Guthrie is 2-3 with a 4.79 ERA in six career starts versus the White Sox and that includes an 0-2 mark and a 7.47 ERA in three appearances at Baltimore.
The Orioles are counting on Guthrie to get them back into the win column after a late collapse in last night's 4-2 loss to Chicago.
Alex Rios came through with a base hit in the eighth to plate the deciding run as the White Sox cooled off the streaking Orioles in the continuation of a four-game series from Camden Yards.
Carlos Quentin homered and A.J. Pierzynski hit a game-tying double in the seventh to erase an early 2-0 deficit and hand Chicago its 10th win in 13 games. The AL Central-leading Pale Hose are 1 1/2 games ahead of Minnesota.
Gavin Floyd (8-8) tossed seven innings of six-hit, two-run ball for his third straight win. It was the first time he surrendered more than one earned run in a span of seven starts.
Matt Thornton fired a scoreless eighth -- his 21st consecutive scoreless appearance -- and J.J. Putz pitched the ninth for his third save of the season.
Adam Jones, who had the game-winning hit in the 10th inning of Friday's opener, homered Saturday and finished with two hits. Ty Wigginton knocked in the other run for the Orioles, who had won a season-high four straight to open the Buck Showalter era.
Jason Berken (3-3) allowed two runs in 1 1/3 innings of relief to suffer the loss. Starter Kevin Millwood went six innings and held the Sox to four hits -- one a solo home run that served as his only run allowed.
"I'm not going to take any credit from their pitching staff, they have been throwing the ball very good against us. I'm glad we scored some runs for Gavin," said White Sox skipper Ozzie Guillen.
The Orioles won five of nine overall meetings with the White Sox last season, including two of three tests held in Baltimore.