The Reds have been perennial also-rans in the NL Central for the better part of a decade.
The Reds have won six of their last eight. The Cubs just broke a seven-game losing streak with a win over the Brewers on Wednesday. Cincinnati sends Bronson Arroyo to face the Cubs' Tom Gorzelanny.
The game will be televised on CSN Chicago beginning with a pregame show at 1 pm CDT.