Suppan has gone 0-3 with a 4.20 earned run average in six starts with the Cardinals following his release from the Milwaukee Brewers. He had been 0-2 with a 7.84 ERA in 15 appearances with the Brewers.
The 35-year-old righty last toed the rubber on Sunday against the Los Angeles Dodgers, but did not get a decision, despite a solid performance that saw him surrender a run and five hits in six innings of his team's 5-4 win.
Suppan lost to the Cubs back on April 23 while with Milwaukee and is 6-10 lifetime against them with a 3.95 ERA in 25 starts.
St. Louis will need a big start from its veteran hurler tonight if it is going to get back in the win column following a 2-0 loss in 11 innings on Thursday to Philadelphia.
Adam Wainwright extended his scoreless innings streak to 25 after giving up six hits while fanning six in six frames for the Cardinals, who had an eight- game win streak stopped. St. Louis advanced just one runner past first base for the duration of the game and had just three baserunners overall.
"I don't worry about this loss," Wainwright said. "We won seven out of eight against two really good clubs. We should be excited about this homestand...It was just one game we lost in extra innings."
With Kyle McClellan (1-3) on to begin the 11th for St. Louis, Placido Polanco put the Phils ahead with a solo home run. They then tacked a run on later in the frame.
Chicago, meanwhile, also enters on a sour note after dropping two of three to the Houston Astros, including a 4-3, 12-inning setback in Wednesday's rubber match.
Bob Howry (1-3) took the loss after allowing two runs on a pair of hits while recording only one out for the Cubs, who have lost three of five.
Chicago, which is 11 games back of the Cardinals for first place in the National League Central, had a chance to win this one, but it stranded runners at second and third in the 11th after Derrek Lee flied out to end the frame.
"There's no secret we're in a bad spot," said Lee of the Cubs position in the standings. "We need to rack up as many wins as possible and the best way to go about that is winning series. Today we had a chance to win one and we let it slip away."
Heading to the hill for the Cubs this afternoon will be righty Randy Wells, who is 4-7 with a 4.33 ERA. Despite tossing seven scoreless innings on Saturday in Philadelphia, Wells did not get a decision in his team's 4-1 setback.
Wells, who is 0-2 in three appearances (two starts) against the Cards, has a 1.66 ERA over his past three starts, but has just one win in his last 14 outings.
St. Louis took two of three from the Cubs earlier in the season at Wrigley.