The two teams have split the first two games of the four-game series, with the White Sox winning 6-1 on Monday, and the Tigers coming through with a 5-3 win on Tuesday.
On Wednesday, Chicago will look to add to its two game lead over the Tigers, but they'll have to do so without Adam Dunn, who is missing his sixth straight game because of an oblique injury.
Both Robin Ventura and Jim Leyland have announced the starting lineups, and they are as follows:
SP Max Scherzer
Chicago White Sox
SP Gavin Floyd
Floyd will be making his first start for the White Sox since Aug. 26. Floyd was placed on the disabled list with a right elbow flexor strain, but is now healthy enough to start.
For more on the White Sox, check out South Side Sox.