The White Sox hit two home runs in the bottom of the sixth to take a 4-1 lead over the rival Tigers through six innings.
Detroit took a 1-0 lead in the second inning, but a combination of defensive errors and pitching mistakes led to a three-run homer by Alex Rios in the sixth to give Chicago a lead. A.J. Pierzynski followed up with a solo shot two pitches later to extend the lead to 4-1 and chase Tigers starter Rick Porcello.
White Sox starter Jose Quintana has allowed seven hits and one walk while striking out six.
Rios is 2-for-3, while Pierzynski is 1-for-3. The Tigers have committed three errors, including two in that sixth inning.