In the bottom of the fifth inning, Youkilis stepped to the plate with the bases loaded and smacked an opposite-field grand slam to put Chicago up 6-2.
That would be enough for White Sox starter Francisco Liriano, who allowed only two earned runs over six innings while striking out seven batters. Reliever Jesse Crain allowed a run on a Russell Martin homer in the top of the seventh, but that would be it for the Yankees, who were blanked by Matt Thornton and Brett Myers.
Paul Konerko also hit his 21st homer of the season for the White Sox.
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