Urlacher returned an interception for a touchdown, forced and a recovered a fumble and recorded seven tackles against the Titans.
This is the sixth time in Urlacher's career that he's been honored with the Defensive Player of the Week award by the league office.
Bears defensive back Charles Tillman has won the award twice for the Bears this season and also earned Defensive Player of the Month honors in October. Bears defensive back Tim Jennings won the Defensive Player of the Month award in September.
Chicago has opened the season with a 7-1 record, which puts the Bears one game behind the 8-0 Atlanta Falcons for the best record in the NFC. The Bears' defense is giving up 318.1 yards per game, which ranks sixth in the league.